Document Detail


Do glucose transporters have other roles in addition to placental glucose transport during early pregnancy?
MedLine Citation:
PMID:  15965666     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human placenta regulates the transport of maternal molecules to the fetus. It is known that glucose transport occurs via glucose transporters (GLUTs) in the feto-placental unit. Data on the expression of GLUTs during implantation are very scarce. Moreover, the question of how the decidual leukocytes obtain the energy for their activation during implantation mechanism is still under investigation. We studied the distributions of GLUT1, GLUT3, and GLUT4 in tissue sections of first trimester pregnancies the human maternal-fetal interface. GLUT1 was present in apical microvilli of the syncytiotrophoblast, in cytotrophoblast, and in vascular patterns of the villous core, whereas GLUT3 was localized in cytotrophoblasts of placental villi and in some fetal endothelial cells. Moreover, the proliferating cells of the proximal cell columns were also immunopositive for GLUT1 and GLUT3. We did not observe any positive immunoreactivity for GLUT4 in placental and decidual tissues. Essentially, GLUT3 and also to some extent GLUT1 was present in maternal leukocytes and platelets. In conclusion, our results suggest that the glucose taken up via GLUT1 and GLUT3 from the maternal circulation might not only be needed for placental functions but also for successful implantation by trophoblast invasion, proliferation and also by having a role to support energy for maternal leukocytes.
Authors:
Emin Turkay Korgun; Ciler Celik-Ozenci; Yasemin Seval; Gernot Desoye; Ramazan Demir
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-06-18
Journal Detail:
Title:  Histochemistry and cell biology     Volume:  123     ISSN:  0948-6143     ISO Abbreviation:  Histochem. Cell Biol.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-07-15     Completed Date:  2005-09-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9506663     Medline TA:  Histochem Cell Biol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  621-9     Citation Subset:  IM    
Affiliation:
Department of Histology and Embryology, Medical Faculty, Akdeniz University, 07070, Antalya, Turkey. korgun@akdeniz.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD / analysis
Antigens, CD45 / analysis
Antigens, Differentiation, Myelomonocytic / analysis
Biological Transport
Female
Glucose / metabolism*
Glucose Transporter Type 1
Glucose Transporter Type 3
Glucose Transporter Type 4
Humans
Immunohistochemistry
Monosaccharide Transport Proteins / analysis,  physiology*
Muscle Proteins / analysis,  physiology
Muscles / chemistry
Myocardium / chemistry
Nerve Tissue Proteins / analysis,  physiology
Placenta / chemistry,  metabolism*
Pregnancy
Pregnancy Trimester, First
Protein Tyrosine Phosphatase, Non-Receptor Type 1
Vimentin / analysis
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, Differentiation, Myelomonocytic; 0/CD68 antigen, human; 0/Glucose Transporter Type 1; 0/Glucose Transporter Type 3; 0/Glucose Transporter Type 4; 0/Monosaccharide Transport Proteins; 0/Muscle Proteins; 0/Nerve Tissue Proteins; 0/SLC2A1 protein, human; 0/SLC2A3 protein, human; 0/SLC2A4 protein, human; 0/Vimentin; 50-99-7/Glucose; EC 3.1.3.48/Antigens, CD45; EC 3.1.3.48/Protein Tyrosine Phosphatase, Non-Receptor Type 1

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