Document Detail


Do functional keratin dressings accelerate epithelialization in human partial thickness wounds? A randomized controlled trial on skin graft donor sites.
MedLine Citation:
PMID:  24058716     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine if the experimental (keratin-based) dressing accelerates epithelialization rates during healing of partial-thickness wounds, relative to a Standard Care dressing.
METHOD: A randomized control trial was conducted using a Standard Care dressing side by side with the experimental dressing on a sample (n=26) of partial-thickness donor site wounds. The proximal/distal placement of the control and treatment was randomized. Percentage epithelialization after approximately 7 days was estimated from which time to fully epithelialize can be inferred. Patients were grouped into "young" (≤50 y/o) and "old" (>50 y/o).
RESULTS: For the "old" patients (n=15), the median epithelialization percentage at 7 days is 5% and was significantly (P=.023) greater for the experimental dressing. For the "young" patients (n=11), the median epithelialization percentage at 7 days was 80% and there is no significant difference between the experimental and Standard Care control dressings.
CONCLUSIONS: The experimental dressing significantly increases the rate of epithelialization of acute, traumatic partial-thickness wounds in older patients. We suggest that the dressing may be clinically useful in similar situations where epithelialization may be delayed because of patient or wound characteristics.
Authors:
Andrew Davidson; N Hamesh Jina; Clive Marsh; Martin Than; Jeremy W Simcock
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Publication Detail:
Type:  Journal Article     Date:  2013-08-29
Journal Detail:
Title:  Eplasty     Volume:  13     ISSN:  1937-5719     ISO Abbreviation:  Eplasty     Publication Date:  2013  
Date Detail:
Created Date:  2013-09-23     Completed Date:  2013-09-23     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101316107     Medline TA:  Eplasty     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e45     Citation Subset:  -    
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