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DO FISH OIL OMEGA-3 FATTY ACIDS ENHANCE ANTIOXIDANT CAPACITY AND MITOCHONDRIAL FATTY ACID OXIDATION IN HUMAN ATRIAL MYOCARDIUM VIA PPARγ ACTIVATION?
MedLine Citation:
PMID:  24597798     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Studies in experimental models suggest n-3 polyunsaturated fatty acids (PUFAs) improve metabolic and anti-inflammatory/antioxidant capacity heart, although the mechanisms are unclear and translational evidence is lacking. In this study, patients ingested a moderately high dose of n-3 PUFAs (3.4 g/day eicosapentaneoic (EPA) and docosahexaneoic acid (DHA) ethyl-esters) for a period of 2-3 weeks prior to having elective cardiac surgery. Blood was obtained before treatment and at time of surgery, and myocardial tissue from right atrium was also dissected during surgery. Blood and myocardial tissue EPA and DHA levels were significantly higher in n-3 PUFA treated patients compared to untreated, standard-of-care control patients. Interestingly, n-3 PUFA patients had greater nuclear transactivation of peroxisome proliferator-activated receptor-γ (PPARγ), fatty acid metabolic gene expression, and enhanced mitochondrial respiration supported by palmitoyl-carnitine in atrial myocardium, despite no difference in mitochondrial content. Myocardial tissue from n-3 PUFA patients also displayed greater expression and activity of key antioxidant/anti-inflammatory enzymes. These findings lead to our hypothesis that PPARγ activation is a mechanism by which fish oil n-3 PUFAs enhance mitochondrial fatty acid oxidation and antioxidant capacity in human atrial myocardium, and that this pre-operative therapeutic regimen may be optimal for mitigating oxidative/inflammatory stress associated with cardiac surgery.
Authors:
Ethan J Anderson; Kathleen Thayne; Mitchel Harris; Saame Raza Shaikh; Timothy M Darden; Daniel S Lark; John Mark Williams; W Randolph Chitwood; Alan P Kypson; Evelio Rodriguez
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-5
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  -     ISSN:  1557-7716     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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