| Do erythropoietic-stimulating agents relieve fatigue? A review of reviews. | |
| | |
MedLine Citation:
|
PMID: 21052957 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Interest in the efficacy and potential deleterious consequences of treatment with erythropoietic-stimulating agents (ESAs) is very high. Recently, the ESAs have come under intense scrutiny as several clinical trials have shown their use to be associated with an increased risk of thrombosis, and a concern for increased mortality risk in oncology. In this context, attention to the effect of ESAs upon fatigue and other aspects of quality of life has tended to be lost. To aid inclusion of this endpoint in the important consideration of risks and benefits of ESA therapy, we summarize the many reviews that have been conducted on this topic. The ten selected reviews were all conducted systematically or were otherwise comprehensive. While these reviews acknowledge an overall positive fatigue or quality-of-life effect, some were equivocal about the meaningfulness or magnitude of the benefit. The overall evidence from these reviews supports a fatigue and overall quality-of-life benefit from treatment with ESAs that is unlikely to be due to chance. This information should be included in the risk/benefit consideration of these controversial agents. |
| | |
Authors:
|
David T Eton; David Cella |
Related Documents
:
|
20163407 - Dilating the vagina to prevent damage from radiotherapy: systematic review of the liter... 19261177 - Building blocks for meta-synthesis: data integration tables for summarising, mapping, a... 20058317 - Laryngeal mucous membrane pemphigoid: a systematic review and pooled-data analysis. 18368407 - Polyarteritis nodosa presenting as pancytopenia: case report and review of the literature. 12891607 - Disassembly of a rotablator: getting out of a trap. 7635117 - Monitoring human tissues for toxic substances: a follow-up to the national academy of s... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Cancer treatment and research Volume: 157 ISSN: 0927-3042 ISO Abbreviation: Cancer Treat. Res. Publication Date: 2011 |
Date Detail:
|
Created Date: 2010-11-05 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8008541 Medline TA: Cancer Treat Res Country: United States |
Other Details:
|
Languages: eng Pagination: 181-94 Citation Subset: IM |
Affiliation:
|
Department of Health Sciences Research, Division of Healthcare Policy & Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. eton.david@mayo.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Summary and comparison of myeloid growth factor guidelines in patients receiving cancer chemotherapy...
Next Document: Ten years of meta-analyses on erythropoiesis-stimulating agents in cancer patients.