| Do different substitution patterns or plant origin in hydroxyethyl starches affect blood coagulation in vitro? | |
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MedLine Citation:
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PMID: 20389236 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The effect of hydroxyethyl starches (HES) on blood coagulation is affected by their molecular weight, their molar substitution and the C2/C6 ratio. The solutions of 6% HES 130/0.4 and 6% HES 130/0.42 have similar molecular weight and molar substitution but different C2/C6 ratio and plant origin. In the present study, the comparative effect of 6% HES 130/0.4 versus 6% HES 130/0.42 on blood coagulation was investigated in vitro. Thirty milliliter of blood was obtained from 10 healthy volunteers and was diluted by 10, 30 and 50% using either 6% HES 130/0.4 or HES 130/0.42, respectively. Blood coagulation was assessed using thrombelastography measurements (clotting time, clot formation time, maximal clot firmness and alpha-angle). The assessment of platelet function was performed with whole blood aggregometry after adding thrombin-receptor-activating protein. No differences were noted between respective dilutions of the two HES. Both colloids produced significant reductions below the reference values range in clotting time at 10, 30 and 50% dilutions. The 50% dilution of both colloids resulted in significant reduction of maximal clot firmness, alpha-angle and platelet aggregation. The present study showed that the corn-derived 6% HES 130/0.4 and the potato-derived 6% HES 130/0.42 have the same effect on blood coagulation in vitro. |
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Authors:
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Paraskevi Matsota; Marianna Politou; Konstantinos Kalimeris; Stella Apostolaki; Efrosyni Merkouri; Argyri Gialeraki; Anthi Travlou; Georgia Kostopanagiotou |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis Volume: 21 ISSN: 1473-5733 ISO Abbreviation: Blood Coagul. Fibrinolysis Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9102551 Medline TA: Blood Coagul Fibrinolysis Country: England |
Other Details:
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Languages: eng Pagination: 448-51 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, University of Athens, 'Attikon' Hospital, Greece. k_kalimeris@hotmail.com <k_kalimeris@hotmail.com> |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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