Document Detail


Do cytoprotective prostaglandins act as mild irritants?
MedLine Citation:
PMID:  7121138     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Of the various mechanisms proposed to explain the cytoprotective properties of prostaglandins, mucus discharge seems the most probable. Mild irritants capable of eliciting mucus release have also been shown to exert cytoprotection. It is suggested that prostaglandins act as mild irritants of the mucosa and that cytoprotection is a mucosal reaction to mild irritation, through stimulation of mucus discharge.
Authors:
M Guslandi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods and findings in experimental and clinical pharmacology     Volume:  4     ISSN:  0379-0355     ISO Abbreviation:  Methods Find Exp Clin Pharmacol     Publication Date:  1982  
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7909595     Medline TA:  Methods Find Exp Clin Pharmacol     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  317-20     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenylate Cyclase / metabolism
Animals
Cell Survival / drug effects
Enzyme Activation / drug effects
Gastric Mucosa / blood supply,  secretion
Ions / metabolism
Irritants*
Mucus / secretion
Prostaglandins / pharmacology*
Regional Blood Flow / drug effects
Chemical
Reg. No./Substance:
0/Ions; 0/Irritants; 0/Prostaglandins; EC 4.6.1.1/Adenylate Cyclase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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