| Do cilia put brakes on the cell cycle? | |
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MedLine Citation:
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PMID: 21460803 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Two papers in this issue show that dynein-binding proteins may regulate the G1-S transition through an effect on cilia. Nde1, a known partner of dynein light chain LC8, controls ciliary length in vitro and in zebrafish, and influences the G1-S progression. The phosphorylation of Tctex1, a dynein light chain, modulates cilia length and accelerates G1-S, thereby regulating proliferation-differentiation decisions in the developing mouse neocortex. |
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Authors:
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Peter K Jackson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nature cell biology Volume: 13 ISSN: 1476-4679 ISO Abbreviation: Nat. Cell Biol. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100890575 Medline TA: Nat Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 340-2 Citation Subset: IM |
Affiliation:
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Genentech Inc, 1 DNA way, MC214, South San Francisco, California 94080, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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