| Do chromosomally abnormal pregnancies really preclude autoimmune etiologies of spontaneous miscarriages? | |
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MedLine Citation:
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PMID: 21195806 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: At least 60% of spontaneous pregnancy loss is considered genetic in nature. Miscarriages can, however, also be autoimmune-induced or have other etiologies. Current clinical dogma in rheumatology as well as obstetrics/gynecology holds that evidence of aneuploidy in products of conception establishes the cause of miscarriage and rules out other potential causes, including autoimmunity. METHODS: This communication reviews published evidence in potential support or repudiation of this dogma via a literature search of appropriate keywords via PubMed and Medline. RESULTS: The literature suggests that maternal autoimmunity, in itself, may increase the risk towards non-dysjunctional events and, therefore, aneuploidy prevalence in abortuses and offspring. CONCLUSIONS: Detection of aneuploidy in products of conception should no longer be considered conclusive evidence of a chromosomally induced miscarriage and that autoimmune evaluations should be withheld. Indeed, an opposite conclusion may have to be reached, suggesting, at least in repeat aborters, careful evaluation of autoimmune status. |
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Authors:
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Norbert Gleicher; Andrea Weghofer; David H Barad |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-12-30 |
Journal Detail:
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Title: Autoimmunity reviews Volume: - ISSN: 1873-0183 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2011-1-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101128967 Medline TA: Autoimmun Rev Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Center for Human Reproduction (CHR)-New York and Foundation for Reproductive Medicine, New York, NY, USA; Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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