| Do chemokines mediate inflammatory cell invasion of the central nervous system parenchyma? | |
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MedLine Citation:
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PMID: 8061859 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inflammatory cell recruitment into the central nervous system (CNS) is a critical step in the response to diverse insults, including infection, trauma and infarction, as well as immune-mediated disorders such as multiple sclerosis (MS). Despite considerable advances in understanding immune surveillance and antigen recognition in the CNS, the signals resulting in parenchymal inflammation are incompletely understood. Members of a novel family of chemo-attractant cytokines, the chemokines, are made in the CNS and are emerging as likely mediators of inflammatory cell migration into the CNS. |
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Authors:
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M Tani; R M Ransohoff |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Brain pathology (Zurich, Switzerland) Volume: 4 ISSN: 1015-6305 ISO Abbreviation: Brain Pathol. Publication Date: 1994 Apr |
Date Detail:
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Created Date: 1994-09-20 Completed Date: 1994-09-20 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9216781 Medline TA: Brain Pathol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 135-43 Citation Subset: IM |
Affiliation:
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Samuel Rosenthal Multiple Sclerosis Research Laboratory, Cleveland Clinic Foundation, OH 44195-5285. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Movement Central Nervous System / physiopathology Central Nervous System Diseases / pathology, physiopathology* Chemotactic Factors / pharmacology, physiology* Cytokines / pharmacology, physiology* Humans Immune System / physiopathology Inflammation / pathology, physiopathology Injections Leukocytes / physiology Receptors, Cytokine / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Chemotactic Factors; 0/Cytokines; 0/Receptors, Cytokine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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