Document Detail

Do carotid chemoreceptors inhibit the hyperventilatory response to heavy exercise?
MedLine Citation:
PMID:  8000358     Owner:  NLM     Status:  MEDLINE    
In this paper two types of evidence are presented which question the commonly presumed role of carotid chemoreceptor stimulation as the primary mediator of the hyperventilatory response to heavy exercise. First, carotid-body denervation in ponies increases their hyperventilatory response to heavy exercise. Second, the awake dog and the goat at rest show an immediate and substantial depression of tidal volume and of ventilation when their isolated carotid chemoreceptors are made hypocapnic. Accordingly, it is proposed that during heavy exercise the carotid chemoreceptors are inhibitory to respiratory motor output and that the cause of the hyperventilatory response originates from extrachemoreceptor, locomotor-linked, feed-forward stimuli.
J A Dempsey; C A Smith
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Canadian journal of applied physiology = Revue canadienne de physiologie appliquée     Volume:  19     ISSN:  1066-7814     ISO Abbreviation:  Can J Appl Physiol     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1995-01-24     Completed Date:  1995-01-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9306274     Medline TA:  Can J Appl Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  350-9     Citation Subset:  IM; S    
John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin-Madison 53705.
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MeSH Terms
Carotid Body / physiology*
Chemoreceptor Cells / physiology
Exercise / physiology*
Hypercapnia / physiopathology
Physical Conditioning, Animal / physiology
Respiration / physiology*

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