| Do cadmium and dexamethasone induce different types of metallothioneins? | |
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MedLine Citation:
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PMID: 2753342 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Dexamethasone induced thionein in rat liver cross reacts with antibody made towards Cd-thionein from rat liver. 2. Dex-thionein binds Cd. 3. Compared to Cd-thionein, dex-thionein behaves differently on SDS polyacrylamide gels. 4. On molecular filtration on Sephadex G-75 columns, dex-thionein elutes slightly more towards the low molecular weight region than Cd-thionein. 5. Dex-thionein elutes in one peak with two shoulders after DEAE-Sephadex A-50 ion exchange chromatography, while Cd-thionein elutes in two peaks. |
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Authors:
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R A Andersen; H L Daae; A Mikalsen; J Alexander |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: General pharmacology Volume: 20 ISSN: 0306-3623 ISO Abbreviation: Gen. Pharmacol. Publication Date: 1989 |
Date Detail:
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Created Date: 1989-08-29 Completed Date: 1989-08-29 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7602417 Medline TA: Gen Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 437-43 Citation Subset: IM |
Affiliation:
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Department of Toxicology, National Institute of Public Health, Oslo, Norway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blotting, Western Cadmium / pharmacology* Chromatography, Gel Chromatography, Ion Exchange Dexamethasone / pharmacology* Electrophoresis, Polyacrylamide Gel Metallothionein / analysis, biosynthesis*, isolation & purification Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/cadmium-binding protein; 50-02-2/Dexamethasone; 7440-43-9/Cadmium; 9038-94-2/Metallothionein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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