Document Detail

Do autologous growth factors enhance transforaminal lumbar interbody fusion?
MedLine Citation:
PMID:  12761669     Owner:  NLM     Status:  MEDLINE    
Pseudarthrosis remains a significant problem in spinal fusion. The objective of our study was to investigate the effects of autologous growth factors (AGF) in instrumented transforaminal lumbar interbody spinal fusion (TLIF). A prospective review was carried out of 23 patients who underwent TLIF with application of AGF, with a minimum 2-year follow-up. Comparison with our historical cohort (without AGF application) was performed. Mean age at surgery was 44.3 years in the AGF treatment group. Twelve had a positive smoking history. Fourteen had undergone previous spinal surgeries. Thirteen received one-level fusions and ten received two-level fusions. The radiographic results showed a fusion rate of 100% in one-level fusions and 90% in two-level fusions. There was no significant difference in pseudarthrosis rates between the AGF treatment group and historical cohort. Excluding the cases with pseudarthrosis, there was faster bony healing in patients who had been treated with AGF application. This study indicates that although AGF may demonstrate faster fusions, it does not result in an overall increase in spinal fusion rates. Further studies are needed before AGF can routinely be used as an adjunct in spinal fusion.
Hwan T Hee; Mohammad E Majd; Richard T Holt; Leann Myers
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Publication Detail:
Type:  Journal Article     Date:  2003-05-22
Journal Detail:
Title:  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society     Volume:  12     ISSN:  0940-6719     ISO Abbreviation:  Eur Spine J     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-09-04     Completed Date:  2004-01-21     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  9301980     Medline TA:  Eur Spine J     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  400-7     Citation Subset:  IM    
Spine Surgery PSC, Louisville, Kentucky, USA.
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MeSH Terms
Bone Transplantation
Cohort Studies
Follow-Up Studies
Growth Substances / therapeutic use*
Intervertebral Disc / radiography,  surgery
Lumbar Vertebrae / radiography,  surgery*
Platelet-Derived Growth Factor / therapeutic use
Prospective Studies
Pseudarthrosis / prevention & control*
Spinal Diseases / radiography,  surgery
Spinal Fusion*
Time Factors
Transforming Growth Factor beta / therapeutic use
Wound Healing
Reg. No./Substance:
0/Growth Substances; 0/Platelet-Derived Growth Factor; 0/Transforming Growth Factor beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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