Document Detail

Do antidepressants have any potential to cause addiction?
MedLine Citation:
PMID:  10512092     Owner:  NLM     Status:  MEDLINE    
Addiction/dependence is a syndrome in which the hallmark is a compulsive pattern of drug use. Most authorities do not regard antidepressants as causing addiction but this has been challenged. This debate is explored drawing on case reports and related clinical and pharmacological data. An extensive literature review identified 21 English language case reports of antidepressant addiction (DSM-IV 'substance dependence' criteria) published since 1963. Sixteen involved tranylcypromine or amineptine and may reflect their dopaminergic and stimulant properties. Subject characteristics included male sex (14/21), personality problems (10/21) and prior substance misuse (14/21). Withdrawal or discontinuation symptoms have long been recognized with antidepressants but other features of addiction such as tolerance and compulsive use are exceptionally rare. Common clinical problems are patients taking subtherapeutic dosages and prematurely stopping antidepressants. The pharmacodynamic profiles of most antidepressants and the absence of acute 'desirable' effects make addiction theoretically unlikely. It is concluded that, with the exception of tranylcypromine and amineptine, antidepressants do not have a clinically significant liability to cause addiction. Tranylcypromine and amineptine should be avoided in those with a history of substance misuse. Patients prescribed other antidepressants should be told that they are not addictive.
P Haddad
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of psychopharmacology (Oxford, England)     Volume:  13     ISSN:  0269-8811     ISO Abbreviation:  J. Psychopharmacol. (Oxford)     Publication Date:  1999  
Date Detail:
Created Date:  1999-11-19     Completed Date:  1999-11-19     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8907828     Medline TA:  J Psychopharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  300-7     Citation Subset:  IM    
Moorside, Trafford General Hospital, Davyhulme, Manchester, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antidepressive Agents / adverse effects*
Substance Withdrawal Syndrome / psychology
Substance-Related Disorders / psychology*
Reg. No./Substance:
0/Antidepressive Agents
Comment In:
J Psychopharmacol. 2000 Jun;14(2):188-92   [PMID:  10890315 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Pharmacological stress diathesis syndromes.
Next Document:  Evidence-based psychopharmacology 1. Appraising a single therapeutic trial: what is the evidence for...