Document Detail

Do angiotensin-converting enzyme (ACE) inhibitors enhance the effect of exercise rehabilitation in patients with hypertension and ACE DD and DI genotypes?
MedLine Citation:
PMID:  17270528     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To test whether pharmacologic angiotensin-converting enzyme (ACE) inhibition in carriers of the ACE DD or DI (D, deletion; I, insertion of 287 base pairs) genotypes can simulate the genetic advantage of the II genotype and thereby enhance the conditioning effects of aerobic exercise. DESIGN: Nonrandomized controlled trial. SETTING: Pulmonary institute. PARTICIPANTS: Twelve sedentary men with controlled hypertension (5 with DD genotype, 7 with DI genotype; age, 53+/-7y) treated by ACE inhibitors (study group) and 10 patients (8 men, 2 women; 2 with DD genotype, 8 with DI genotype; age, 54+/-10y) who were treated by other antihypertensive drugs (controls). INTERVENTION: Exercise training. MAIN OUTCOME MEASURES: Training effect was measured by maximal oxygen uptake (Vo(2)max) anaerobic threshold (Vo(2AT)), and the corresponding work rates (WR) (in watts)-WRmax and WR(AT)-before and after 10 weeks of training. RESULTS: Vo(2)max increased by a mean of 10% (200mL/min) and WRmax by 14% (25W) in each group (P<.001). Vo(2AT) and WR(AT) tended to increase more in the study group (Vo(2AT): 10% [186+/-35mL/min] vs 5% [100+/-1mL/min]; P<.006; WR(AT): 19% [19+/-2W] vs 12% [11+/-3W]; P<.03; respectively). CONCLUSIONS: This study did not show an enhancement of exercise-related conditioning by pharmacologic ACE inhibition among hypertensive patients with ACE DD and DI genotypes, comparable to the advantage conferred by the II genotype.
Yaniv Duzli; Ehud Grossman; Mark Gaides; Shlomo Segev; Norit Gal; Issahar Ben-Dov
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of physical medicine and rehabilitation     Volume:  88     ISSN:  0003-9993     ISO Abbreviation:  Arch Phys Med Rehabil     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-02     Completed Date:  2007-03-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985158R     Medline TA:  Arch Phys Med Rehabil     Country:  United States    
Other Details:
Languages:  eng     Pagination:  262-4     Citation Subset:  AIM; IM    
Pulmonary Institute, The Chaim Sheba Medical Center, Tel-Hashomer, Israel.
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MeSH Terms
Anaerobic Threshold / physiology
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
Exercise Tolerance / physiology
Gene Deletion
Hypertension / genetics*,  physiopathology,  rehabilitation*
Middle Aged
Oxygen Consumption / physiology
Peptidyl-Dipeptidase A / genetics*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; EC A

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