Document Detail

Do subtypes of graves' orbitopathy exist?
MedLine Citation:
PMID:  20673587     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To describe the prevalence of fat and muscle volume (MV) increase in Graves' orbitopathy (GO) patients, calculated from computed tomography scans, and the associated ophthalmic and endocrine characteristics.
DESIGN: Consecutive, observational case series.
PARTICIPANTS: Ninety-five consecutive Caucasian GO patients attending the thyroid eye clinic.
METHODS: Volumetry using age-specific reference values in untreated GO patients who had been rendered euthyroid.
MAIN OUTCOME MEASURES: Subgroups in GO and main characteristics.
RESULTS: Four subgroups could be distinguished: Group 1, no fat volume (FV) or MV increase (n = 24); group 2, only FV increase (n = 5); group 3, only MV increase (n = 58); and group 4, both FV and MV increase (n = 8). Patients with an increase of MV were older and had higher thyroid-stimulating hormone-binding inhibitory immunoglobulin TBII, more proptosis, and more impaired ductions than those without MV increase. Patients with an increase of FV differed from those without FV increase only in having more proptosis. The clinical activity score did not differ between the 4 groups.
CONCLUSIONS: Of these GO patients, 25% have orbital fat and MVs within an age-specific reference range. An increase of the FV is seen in only 14% of GO patients and characterized by proptosis. Muscle enlargement occurs in 70% of patients and is associated with older age, higher TBII values, more proptosis, and impaired motility.
Noortje I Regensburg; Wilmar M Wiersinga; Tos T J M Berendschot; Peter Potgieser; Maarten P Mourits
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-29
Journal Detail:
Title:  Ophthalmology     Volume:  118     ISSN:  1549-4713     ISO Abbreviation:  Ophthalmology     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-04     Completed Date:  2011-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802443     Medline TA:  Ophthalmology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  191-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.
Orbital Centre, Department of Ophthalmology, Academic Medical Centre, University of Amsterdam, The Netherlands.
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MeSH Terms
Adipose Tissue / pathology*,  radiography
Graves Ophthalmopathy / classification*,  radiography
Middle Aged
Oculomotor Muscles / pathology*,  radiography
Orbital Diseases / classification*,  radiography
Tomography, X-Ray Computed

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