Document Detail

Do Patients with Non-Arteritic Ischemic Optic Neuritis Have Increased Risk for Cardiovascular and Cerebrovascular Events?.
MedLine Citation:
PMID:  23364133     Owner:  NLM     Status:  Publisher    
Objectives: To compare the incidence of cardiac and cerebrovascular events following non-arteritic anterior ischemic optic neuropathy (NAION) compared to published control data using the Framingham, United Kingdom Prospective Diabetes Study (UKPDS) and the National Vascular Disease Prevention Alliance (NVDPA) data. Methods: A retrospective study of all consecutive cases of NAION between 1990 and 2005. Patients were stratified into those with or without prior ischemic events and into diabetics and non-diabetics. Outcome measures included cardiovascular morbidity, cerebrovascular events and the Framingham, UKPDS and NVDPA scores for each patient. Results: According to the NVDPA, the average absolute 5-year risk for cardiovascular disease (CVD) was 8.98, compared to 9 CVD events in our study. In the diabetic patients, 5 (17%) had a cardiac event and 2 (8%) had a cerebral vascular accident (CVA). Based on the UKPDS risk calculator, the average 10-year risk for cardiac events is 21.6%, CVA -6.8%. In the non-diabetics, there were 3 cases (7.5%) of myocardial infarction, compared to the average 10-year Framingham risk for myocardial infarction or coronary death of 11% (±8 SD). Conclusions: Following NAION, the incidence of cardiovascular or cerebrovascular events in patients taking aspirin is not in major excess from that expected in risk-factor age-matched controls.
Murat Hasanreisoglu; Eyal Robenshtok; David Ezrahi; Hadas Stiebel-Kalish
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-24
Journal Detail:
Title:  Neuroepidemiology     Volume:  40     ISSN:  1423-0208     ISO Abbreviation:  Neuroepidemiology     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8218700     Medline TA:  Neuroepidemiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  220-224     Citation Subset:  -    
Copyright Information:
Copyright © 2013 S. Karger AG, Basel.
Neuro-Ophthalmology Unit, Rabin Medical Center, Petach Tikva, Israel.
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