Document Detail

Do manualized psychosocial interventions help reduce relapse among alcohol-dependent adults treated with naltrexone or placebo? A meta-analysis.
MedLine Citation:
PMID:  23082827     Owner:  NLM     Status:  MEDLINE    
BACKGROUND:  During the past decade, several novel medication treatments and psychosocial interventions have been tested. Overall, their impact on reducing alcohol use and preventing relapse has been modest. These outcomes have spurred researchers to investigate whether the addition of manualized psychosocial therapies with demonstrated efficacy to pharmacotherpy would have a synergistic effect.
OBJECTIVES:  We conducted a meta-analysis to test the hypothesis that the addition of manualized psychosocial therapies would reduce the frequency of relapse.
RESULTS:  This review analyzed data from six studies. Among studies that used random assignment to manually guided psychosocial interventions, the rates of relapse between the naltrexone plus a psychosocial intervention and naltrexone without a psychosocial intervention were very similar. Among patients allocated to placebo, similar rates of relapse were also found between Cognitive Behavioral Therapy (CBT) and non-CBT. In studies which used manualized psychotherapies as a platform, relapse rates were similar between naltrexone and placebo. In contrast, studies using Treatment As Usual psychotherapy as a platform demonstrated lower rates of relapse in the naltrexone group, compared to placebo group.
CONCLUSIONS:  We conclude that CBT does not appear to offer benefits beyond those derived from study medications.
SCIENTIFIC SIGNIFICANCE:  The benefit of the addition of CBT to medication in preventing relapse may be limited.
Vito Agosti; Edward V Nunes; Donna O'Shea
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Review     Date:  2012-09-21
Journal Detail:
Title:  The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions     Volume:  21     ISSN:  1521-0391     ISO Abbreviation:  Am J Addict     Publication Date:    2012 Nov-Dec
Date Detail:
Created Date:  2012-10-22     Completed Date:  2013-04-16     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  9208821     Medline TA:  Am J Addict     Country:  England    
Other Details:
Languages:  eng     Pagination:  501-7     Citation Subset:  IM    
Copyright Information:
Copyright © American Academy of Addiction Psychiatry.
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MeSH Terms
Alcoholism / therapy*
Cognitive Therapy / methods*
Combined Modality Therapy
Middle Aged
Naltrexone / therapeutic use*
Narcotic Antagonists / therapeutic use*
Recurrence / prevention & control
Reg. No./Substance:
0/Narcotic Antagonists; 5S6W795CQM/Naltrexone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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