| Do MDL-1⁺ cells play a broad role in acute inflammation? | |
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MedLine Citation:
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PMID: 22005298 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dengue virus (DV) reacts with myeloid DAP12-associating lectin-1 (MDL-1) on immature polymorphonuclear leukocytes. Interaction of DV with MDL-1+ cells triggers systemic inflammatory response syndrome (SIRS) and dengue shock syndrome (DSS), with subsequent multi-organ failure. In this issue of the JCI, Cheung et al. find that sterile acute liver injury in mice is associated with the accumulation of MDL-1+ cells and that triggering of these cells by DV or an MDL-1-specific agonist antibody leads to SIRS, shock, and death. These findings may have broad mechanistic and therapeutic implications for the development of SIRS, sepsis, and shock in humans exposed to a wide array of infectious and non-infectious conditions. |
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Authors:
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Peter A Ward |
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Publication Detail:
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Type: Comment; Journal Article; Research Support, N.I.H., Extramural Date: 2011-10-17 |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 121 ISSN: 1558-8238 ISO Abbreviation: J. Clin. Invest. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-02 Completed Date: 2012-01-03 Revised Date: 2012-02-07 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 4234-7 Citation Subset: AIM; IM |
Affiliation:
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University of Michigan Medical School, Department of Pathology, Ann Arbor, Michigan, USA. pward@umich.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Humans Lectins, C-Type / immunology* Myeloid Cells / immunology* Receptors, Cell Surface / immunology* Shock / etiology*, immunology* |
| Grant Support | |
ID/Acronym/Agency:
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GM-29507/GM/NIGMS NIH HHS; GM-61656/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Clec5a protein, mouse; 0/Lectins, C-Type; 0/Receptors, Cell Surface |
| Comments/Corrections | |
Comment On:
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J Clin Invest. 2011 Nov;121(11):4446-61
[PMID:
22005300
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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