| Do Local Meteorological Conditions Influence Skin Irritation Caused by Transdermal Rivastigmine?: A Retroprospective, Pilot Study. | |
| | |
MedLine Citation:
|
PMID: 22544007 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: This retrospective study aimed to evaluate the incidence of transdermal rivastigmine treatment withdrawal secondary to adverse skin reactions among the patients from our Memory Clinic. In addition, we tested whether climatic conditions might have an influence on skin irritations leading to eventual treatment disruption. METHODS: We performed a retrospective review of patients from the Brugmann University Hospital Memory Clinic having started transdermal rivastigmine between June 2008 and December 2010. Local meteorological data were provided by the Royal Meteorological Institute of Belgium. RESULTS: A total of 26.9% of the patients experienced adverse skin reactions at the rivastigmine application site, leading to treatment discontinuation in 19.2% of the cases. Rivastigmine cutaneous tolerability was not found to be related to demographic parameters, Mini Mental Status Examination score, or type of dementia. High temperature and low air humidity during the first month of treatment were found to be associated with a higher incidence of skin reactions and secondary treatment disruption. CONCLUSIONS: Transdermal rivastigmine induced a higher incidence of cutaneous adverse events than previously reported in a prospective clinical trial. Moreover, it seems that meteorological conditions favoring skin perspiration (high temperature and low air humidity) during the first month of treatment might have an influence on transdermal rivastigmine skin tolerability. |
| | |
Authors:
|
Kurt Segers; Ephraim Cytryn; Murielle Surquin |
Related Documents
:
|
17125957 - The effect of patient-centered contraceptive counseling in women who undergo a voluntar... 18320917 - Benefits and risks of danazol in hereditary angioedema: a long-term survey of 118 patie... 8840707 - The effect of sperm-mucus interaction test on the outcome of in vitro fertilization and... 8485607 - Comparative efficacy of gestrinone and danazol in infertile women with endometriosis. 3551617 - Effectiveness of ketorolac tromethamine 0.5% ophthalmic solution for chronic aphakic an... 20227617 - Interocular axial length difference as a predictor of postoperative visual acuity after... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-4-26 |
Journal Detail:
|
Title: Journal of clinical psychopharmacology Volume: - ISSN: 1533-712X ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
|
Created Date: 2012-4-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8109496 Medline TA: J Clin Psychopharmacol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
From the *Neurology Department and †Geriatrics Department, Brugmann University Hospital, Brussels, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prevalence of Concomitant Oral Antipsychotic Drug Use Among Patients Treated With Long-Acting, Intra...
Next Document: From Disordered Eating to Addiction: The "Food Drug" in Bulimia Nervosa.