| Do HbA1C Levels Correlate With Delayed Gastric Emptying in Diabetic Patients? | |
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MedLine Citation:
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PMID: 21103423 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Gastroparesis is characterized by delayed gastric emptying without obstruction. Diabetes is frequently associated with poor glycemic control and delayed gastric emptying. Gastric emptying scintigraphy (GES) is the standard for measuring gastric emptying. Serum hemoglobin A1C (HbA1C) measures prolonged glycemic control with normal as < 7% glycated. To date, no correlation of serum HbA1C level with gastric emptying, demonstrated by GES, in diabetics has been performed. The aim of the present investigation is to determine if a relationship exists between serum HbA1C levels and gastric emptying, assessed by GES, in diabetics. METHODS: All diabetics, having both GES and serum HbA1C level within 3 months from July 1, 2003 - June 30, 2008 were eligible for study. Demographic data collected included gender, age and ethnicity. Abnormal gastric emptying was defined as T½ > 120 minutes and serum HbA1C as percent glycated. RESULTS: Nuclear Medicine GES database review revealed 431 examinations performed during the study interval. A total of 181 were not eligible due to the following: 29 duplicates, 22 diabetes not documented and 130 without HbA1C levels, resulting a study group of 250 cases. No significant correlation was observed between gastric emptying time, HbA1C or age. Among patients with HbA1C ≥ 7%, HbA1C was inversely related to age with a coefficient of correlation of r = -0.175 (p = 0.038). CONCLUSIONS: There is no correlation observed between gastric emptying time, using GES, and serum HbA1C levels. In diabetics, serum HbA1C is not as important as daily glycemic control regarding gastric emptying. |
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Authors:
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Shilpa Reddy; Karishma Ramsubeik; Kenneth J Vega; Justin Federico; Carlos Palacio |
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Publication Detail:
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Type: Journal Article Date: 2010-10-30 |
Journal Detail:
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Title: Journal of neurogastroenterology and motility Volume: 16 ISSN: 2093-0887 ISO Abbreviation: J Neurogastroenterol Motil Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101530189 Medline TA: J Neurogastroenterol Motil Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 414-7 Citation Subset: - |
Affiliation:
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Department of Medicine, University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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