| Do Genetic Variations Alter the Effects of Exercise Training on Cardiovascular Disease and Can We Identify the Candidate Variants Now or In the Future? | |
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MedLine Citation:
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PMID: 21565989 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Cardiovascular disease (CVD) and CVD risk factors are highly heritable and numerous lines of evidence indicate they have a strong genetic basis. While there is nothing known about the interactive effects of genetics and exercise training on CVD itself, there is at least some literature addressing their interactive effect on CVD risk factors. There is some evidence indicating that CVD risk factor responses to exercise training are also heritable and, thus, may have a genetic basis. While roughly one hundred studies have reported significant effects of genetic variants on CVD risk factor responses to exercise training, no definitive conclusions can be generated at the present time, because of the lack of consistent and replicated results and the small sample sizes evident in most studies. There is some evidence supporting "possible" candidate genes that may affect these responses to exercise training - APO E and CETP for plasma lipoprotein-lipid profiles, eNOS, ACE, EDN1, and GNB3 for blood pressure, PPARG for type 2 diabetes phenotypes, and FTO and BAR genes for obesity-related phenotypes. However, while genotyping technologies and statistical methods are advancing rapidly, the primary limitation in this field, is the need to generate what in terms of exercise intervention studies would be almost incomprehensible sample sizes. Most recent diabetes, obesity, and blood pressure genetic studies have utilized populations of 10,000 to 250,000 subjects, which result in the necessary statistical power to detect the magnitude of effects that would probably be expected for the impact of individual gene on CVD risk factor responses to exercise training. Thus, at this time it is difficult to see how this field will advance in the future to the point where robust, consistent, and replicated are available to address these issues. |
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Authors:
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James M Hagberg |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-12 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Maryland. |
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