| Do GABA uptake inhibitors herald a new generation of GABA-ergic drugs for trigeminal neuralgia? | |
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MedLine Citation:
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PMID: 16479860 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anticonvulsant drugs are the initial treatment of choice in trigeminal neuralgia. Historically, carbamazepine is and remains the gold standard. Many similarities between the pathophysiologic phenomena observed in epilepsy models and neuropathic pain models justify the rationale for the use of anticonvulsants in the management of neuropathic pain disorders. We have evidence that there is a high intensity of Gamma-aminobutyric acid transporters in the trigeminal sensory nuclei, and that Gamma-aminobutyric transporters expression was increased in the spinal trigeminal nucleus of rats after facial carrageenan injections. These are correlated with increased Gamma-aminobutyric acid uptake in the synaptosomal preparation from the spinal trigeminal nucleus of rats that received the injections and can be antagonised with glial uptake inhibitors. We conclude that Gamma-aminobutyric acid uptake inhibitors may prove to be a novel generation of GABAergic drugs for trigeminal neuralgia. |
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Authors:
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Ng Chee Hon |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of the Royal Australasian College of Dental Surgeons Volume: 17 ISSN: 0158-1570 ISO Abbreviation: Ann R Australas Coll Dent Surg Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2006-02-16 Completed Date: 2006-04-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8006208 Medline TA: Ann R Australas Coll Dent Surg Country: Australia |
Other Details:
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Languages: eng Pagination: 70-2 Citation Subset: D |
Affiliation:
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Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, National University of Singapore. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anticonvulsants
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therapeutic use Carbamazepine / therapeutic use GABA Plasma Membrane Transport Proteins / physiology* Humans Neurotransmitter Uptake Inhibitors / therapeutic use* Trigeminal Neuralgia / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/GABA Plasma Membrane Transport Proteins; 0/Neurotransmitter Uptake Inhibitors; 298-46-4/Carbamazepine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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