Document Detail


Do FADS genotypes enhance our knowledge about fatty acid related phenotypes?
MedLine Citation:
PMID:  19948371     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several physiological processes, such as visual and cognitive development in early life, are dependent on the availability of long-chain polyunsaturated fatty acids (LC-PUFAs). Furthermore, the concentration of LC-PUFAs in phospholipids has been associated with numerous complex diseases like cardiovascular disease, atopic disease and metabolic syndrome. The level and composition of LC-PUFAs in the human body is mainly dependent on their dietary intake or on the intake of fatty acid precursors, which are endogenously elongated and desaturated to physiologically active LC-PUFAs. The delta-5 and delta-6 desaturase are the most important enzymes in this reaction cascade. In the last few years, several studies have reported an association between single nucleotide polymorphisms (SNPs) in the two desaturase encoding genes (FADS1 and FADS2) and the concentration of omega-6 and omega-3 fatty acids. This shows that beside nutrition, genetic factors play an important role in the regulation of LC-PUFAs as well. This review focuses on current knowledge of the impact of FADS genotypes on LC-PUFA and lipid metabolism and discusses their influence on infant intellectual development, neurological conditions, metabolic disease as well as cardiovascular disease.
Authors:
Eva Lattka; Thomas Illig; Joachim Heinrich; Berthold Koletzko
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-11-30
Journal Detail:
Title:  Clinical nutrition (Edinburgh, Scotland)     Volume:  29     ISSN:  1532-1983     ISO Abbreviation:  Clin Nutr     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-07     Completed Date:  2010-09-28     Revised Date:  2010-10-06    
Medline Journal Info:
Nlm Unique ID:  8309603     Medline TA:  Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  277-87     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
Affiliation:
Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Child
Fatty Acid Desaturases / genetics*
Fatty Acids / metabolism*
Fatty Acids, Unsaturated / metabolism
Genotype
Humans
Infant
Multigene Family
Phenotype
Polymorphism, Genetic
Stearoyl-CoA Desaturase / genetics*
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Unsaturated; EC 1.14.19.-/Fatty Acid Desaturases; EC 1.14.19.1/Stearoyl-CoA Desaturase; EC 1.14.19.3/FADS2 protein, human; EC 1.14.19.3/FADS3 protein, human; EC 1.14.99.-/delta-5 fatty acid desaturase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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