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Do Escherichia coli extract and cranberry exert preventive effects on chronic bacterial prostatitis? Pilot study using an animal model.
MedLine Citation:
PMID:  21042827     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Traditional first-line treatment of chronic bacterial prostatitis (CBP) is administration of empirical antibiotics. However, the efficacy rate is low and long-term antibiotic therapy can result in adverse events and bacterial resistance. For these reasons, a new treatment or preventive modality that can replace traditional antibiotic therapy is required. There are several reports that E. coli extract has a preventive effect on recurrent urinary tract infection (UTI). Cranberries are also known to have beneficial effects in preventing UTI. To evaluate the preventive effect of E. coli extract and cranberries on CBP, 48 rats were randomly divided into 4 groups; control, ciprofloxacin, E. coli extract, and cranberry groups. All drug treatments were conducted for 3 weeks, and then we developed a CBP rat model. After 4 weeks, the results of microbiological culture of prostate and urine samples as well as histological findings for the prostate were analyzed for each group. The infection rate in the ciprofloxacin group was significantly lower than that in the control group. The microbiological cultures of the prostate and urine samples demonstrated reduced bacterial growth in all experimental groups compared with the control group. Histopathologic examination showed significantly decreased prostatic inflammation in all groups compared with the control group. These results suggest that E. coli extract has a potential preventive effect on the development of CBP, and cranberry also exhibits promising activity in this context.
Authors:
Sang Hoon Kim; U-Syn Ha; Hyun Rim Lee; Dong Wan Sohn; Seung-Ju Lee; Hyun Woo Kim; Chang Hee Han; Choong Bum Lee; Yong-Hyun Cho
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Publication Detail:
Type:  Journal Article     Date:  2010-11-02
Journal Detail:
Title:  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy     Volume:  17     ISSN:  1437-7780     ISO Abbreviation:  J. Infect. Chemother.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9608375     Medline TA:  J Infect Chemother     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  322-6     Citation Subset:  IM    
Affiliation:
Department of Urology, St Mary's Hospital, The Catholic University of Korea College of Medicine, 62 Youido-dong, Youngdungpoku, Seoul, 150-713, Korea.
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