| Do the effects of testosterone on muscle strength, physical function, body composition, and quality of life persist six months after treatment in intermediate-frail and frail elderly men? | |
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MedLine Citation:
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PMID: 21084399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Short-term testosterone (T) treatment in frail elderly men improves muscle mass and strength. It is unclear whether these effects can be maintained post treatment. OBJECTIVE: To assess the durability of androgen effects in frail men. DESIGN AND SETTING: Single center, randomized, double-blind, placebo-controlled trial to investigate the effects of 6 months T (25-75 mg daily) on muscle strength, body composition, physical function, and quality of life (QoL). Participants were assessed at the end of treatment (6 months) and 6 months after treatment cessation (12 months). PARTICIPANTS: 274 intermediate-frail and frail elderly men aged 65-90 years with low T levels. RESULTS: Mean T increased from 11.1 (3.1) nmol/liter at baseline to 18.4 (3.5) nmol/liter at 6 months, then declined to 10.5 (3.7) nmol/L at 12 months, in the T-treated group. Isometric knee extension peak torque increased in the T-treated group compared with placebo to give an adjusted mean difference (95% CI) between groups of 8.1 (-0.2 to 16.5) Nm at 6 months. Lean mass increased in the T-treated group giving a difference between groups of 1.2 (0.8 to 1.7) kg at 6 months. Somatic and sexual symptoms improved during treatment. None of these differences between groups remained at 12 months. Prostate specific antigen (PSA) levels and haematocrit increased slightly during treatment but returned to baseline by 12 months. CONCLUSION: The effects of 6-month T treatment on muscle strength, lean mass, and QoL in frail men are not maintained at 6 months post treatment. |
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Authors:
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Matthew D L O'Connell; Stephen A Roberts; Upendram Srinivas-Shankar; Abdelouahid Tajar; Martin J Connolly; Judith E Adams; Jackie A Oldham; Frederick C W Wu |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-11-17 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 96 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-07 Completed Date: 2011-03-21 Revised Date: 2012-02-16 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 454-8 Citation Subset: AIM; IM |
Affiliation:
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Andrology Research Unit, Manchester Academic Health Science Centre, Manchester Royal Infirmary, The University of Manchester, Manchester, United Kingdom. |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00190060 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Aged Aged, 80 and over Body Composition / drug effects* Cholesterol, HDL / blood Double-Blind Method Frail Elderly* Hematocrit Humans Isometric Contraction Luteinizing Hormone / blood Male Motor Activity / drug effects*, physiology* Muscle Strength / drug effects* Prostate-Specific Antigen / blood Quality of Life* Sex Hormone-Binding Globulin / metabolism Sexual Behavior Testosterone / adverse effects, blood, pharmacology* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Sex Hormone-Binding Globulin; 58-22-0/Testosterone; 9002-67-9/Luteinizing Hormone; EC 3.4.21.77/Prostate-Specific Antigen |
| Comments/Corrections | |
Comment In:
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J Urol. 2012 Feb;187(2):622
[PMID:
22237359
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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