| Do DNA sequence variants in ABCA1 contribute to HDL cholesterol levels in the general population? | |
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MedLine Citation:
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PMID: 15520856 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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HDL has a key role in reverse cholesterol transport, mobilizing cholesterol from the peripheral tissues to liver. In this process, the ABC transporter A1 (ABCA1) protein controls the efflux of intracellular cholesterol to apoAI, the major apolipoprotein of HDL. Since ABCA1 mutations were discovered to cause Tangier disease, a rare recessive HDL deficiency, it has been speculated that sequence variants in ABCA1 might also contribute to variations in plasma HDL cholesterol levels in the general population. A new study provides genetic evidence supporting this hypothesis. |
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Authors:
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Päivi Pajukanta |
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Publication Detail:
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Type: Comment; Journal Article; Review |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 114 ISSN: 0021-9738 ISO Abbreviation: J. Clin. Invest. Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-11-02 Completed Date: 2004-12-13 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 1244-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, California 90095-7088, USA. ppajukanta@mednet.ucla.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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ATP-Binding Cassette Transporters
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blood,
genetics* Cholesterol / metabolism Cholesterol, HDL / blood*, genetics Exons Genetic Variation Humans Lipid Metabolism Liver / metabolism Models, Biological Mutation Phenotype Tangier Disease / genetics |
| Chemical | |
Reg. No./Substance:
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0/ATP binding cassette transporter 1; 0/ATP-Binding Cassette Transporters; 0/Cholesterol, HDL; 57-88-5/Cholesterol |
| Comments/Corrections | |
Comment On:
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J Clin Invest. 2004 Nov;114(9):1343-53
[PMID:
15520867
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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