| Do cytokines contribute to the Andean-associated protection from reduced fetal growth at high altitude? | |
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MedLine Citation:
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PMID: 20841404 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pro- versus anti-inflammatory cytokine balance is important for successful pregnancy. Chronic hypoxia alters cytokine levels and increases the frequency of fetal growth restriction (FGR). Multigenerational Andean (AND) versus shorter duration European (EUR) high-altitude (HA) residents are protected from altitude-associated FGR. To address whether ancestry group differences in cytokine levels were involved, we conducted serial studies in 56 low-altitude ([LA]; 400 m; n = 29 AND and n = 27 EUR) and 42 HA residents (3600-4100 m; n = 19 ANDs and n = 23 EURs). Pregnancy raised pro- (interleukin 1β [IL-1β]) and anti- (IL-10) inflammatory cytokines and HA lowered IL-6 and tumor necrosis factor-α (TNF-α) near term. There were no ancestry group differences in cytokine levels at any time, but HA reduced IL-1β in ANDs only near term. Higher IL-1β levels correlated with uterine artery (UA) blood flow at 20 weeks in ANDs at HA, suggesting that IL-1β may play a role in AND protection from altitude-associated reductions in fetal growth. |
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Authors:
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R Daniela Dávila; Colleen G Julian; Megan J Wilson; Vaughn A Browne; Carmelo Rodriguez; Abigail W Bigham; Mark D Shriver; Enrique Vargas; Lorna G Moore |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-09-14 |
Journal Detail:
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Title: Reproductive sciences (Thousand Oaks, Calif.) Volume: 18 ISSN: 1933-7205 ISO Abbreviation: Reprod Sci Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-23 Completed Date: 2011-04-11 Revised Date: 2011-07-25 |
Medline Journal Info:
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Nlm Unique ID: 101291249 Medline TA: Reprod Sci Country: United States |
Other Details:
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Languages: eng Pagination: 79-87 Citation Subset: IM |
Affiliation:
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Altitude Research Center, University of Colorado Denver, Aurora, CO 80045, USA. daniela.davila@ucdenver.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Altitude* Blood Flow Velocity Bolivia Cytokines / blood, physiology* European Continental Ancestry Group Female Fetal Growth Retardation* / etiology, physiopathology, prevention & control Gestational Age Humans Indians, South American Interleukin 1 Receptor Antagonist Protein / blood Interleukin-10 / blood Interleukin-1beta / blood, physiology* Interleukin-4 / blood Interleukin-6 / blood Pregnancy Tumor Necrosis Factor-alpha / blood Uterine Artery / physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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HL07171/HL/NHLBI NIH HHS; HL079647/HL/NHLBI NIH HHS; HL60131/HL/NHLBI NIH HHS; R01 HL079647-01/HL/NHLBI NIH HHS; R01 HL079647-05/HL/NHLBI NIH HHS; R03 TW001188-01/TW/FIC NIH HHS; R03 TW007957-03/TW/FIC NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Interleukin 1 Receptor Antagonist Protein; 0/Interleukin-1beta; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10; 207137-56-2/Interleukin-4 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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