Document Detail

Do Clinical Outcomes in Chronic Hemodialysis Depend on the Choice of a Dialyzer?
MedLine Citation:
PMID:  21323999     Owner:  NLM     Status:  Publisher    
Nephrologists are presented with a range of choices when selecting a dialyzer for chronic hemodialysis. Dialyzers differ in the material, structure, permeability and surface area of their membrane, and how the dialyzer is sterilized. Opinions vary regarding the impact of dialyzer characteristics on patient outcomes and which, if any, of these properties to take into account when choosing a dialyzer can be confusing. In the general dialysis population, there is no compelling evidence that the choice of a membrane material from among those materials currently in clinical use has a significant impact on morbidity or mortality (although there are rare patients who will react adversely to a given dialysis membrane). Similarly, most dialyzers are capable of adequately removing small solutes, such as urea, provided they are used with an appropriate blood flow rate and treatment time to ensure delivery of a single-pool Kt/V(urea) of at least 1.25 for men and 1.65 for women. However, in some dialysis patient subpopulations, the results of randomized clinical trials suggest that use of dialyzer containing high-flux membranes confers an outcome advantage. The extent to which this advantage is realized might also depend on how the dialyzer is used, with application in convective therapies such as hemodiafiltration being superior to diffusive therapies such as hemodialysis. This possibility is currently the subject of several large clinical trials.
Richard A Ward
Related Documents :
11161309 - A novel method of preparation of small intestinal brush border membrane vesicles by pol...
2448709 - Gm1 ganglioside enhances synaptosomal resistance to chemically induced damage.
6937459 - Contribution to the physicochemical rationale for the caries reducing effect of fluoride.
15468839 - In vitro differences of hydroxyapatite from different resources in simulated body fluid.
8633769 - Extraction of serum and urine calcium with ion exchange membrane filters for isotope en...
16853209 - Precursor decomposition and nucleation kinetics during platelike apatite synthesis.
20734329 - The lambda spanin components rz and rz1 undergo tertiary and quaternary rearrangements ...
19014049 - Comparing body temperature measurements by mothers and physicians using mercury-in-glas...
20134849 - Refractive index of nd:caf(2) and some nd doped glasses as a function of wavelength, % ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-17
Journal Detail:
Title:  Seminars in dialysis     Volume:  -     ISSN:  1525-139X     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8911629     Medline TA:  Semin Dial     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Wiley Periodicals, Inc.
Department of Medicine, University of Louisville, Louisville, Kentucky.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cherry Picking in ESRD: An Ethical Challenge in the Era of Pay for Performance.
Next Document:  Extracorporeal Treatment of Cast Nephropathy.