| Do the blood pressure effects of nonsteroidal antiinflammatory drugs influence cardiovascular morbidity and mortality? | |
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MedLine Citation:
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PMID: 20524091 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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There are many theories about why selective inhibitors of the second isoform of cyclooxygenase (COX-2) increase cardiovascular risk. Although torcetrapib raises blood pressure and cardiovascular risk, it has been difficult to prove such a link for COX-2 inhibitors in randomized clinical trials. This review shows a significant correlation in placebo-controlled trials between the five agents' elevations in blood pressures and their rate ratios for cardiovascular events. A larger body of evidence arises from randomized clinical trial comparisons of selective versus nonselective inhibitors of COX-2, but these results are heterogeneous for naproxen versus other traditional agents. The best current trial evidence comes from the centrally adjudicated placebo-controlled trials of celecoxib for colonic polyps: If the blood pressure did not rise at 1 or 3 years after randomization, cardiovascular risk did not significantly increase. Many more data will become available in 2013, after the only prospective clinical trial involving cardiovascular end points is completed. |
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Authors:
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William J Elliott |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current hypertension reports Volume: 12 ISSN: 1534-3111 ISO Abbreviation: Curr. Hypertens. Rep. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888982 Medline TA: Curr Hypertens Rep Country: United States |
Other Details:
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Languages: eng Pagination: 258-66 Citation Subset: IM |
Affiliation:
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Division of Pharmacology, Pacific Northwest University of Health Sciences, 200 University Parkway, Yakima, WA 98901, USA. wj.elliott@yahoo.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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