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Do Black (dark) Lymph Node Metastases in Papillary Thyroid Carcinoma Suggest more Advanced or Aggressive Disease?
MedLine Citation:
PMID:  23343222     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: In some patients papillary thyroid carcinoma (PTC) lymph node metastases are noted to be black (dark) in color at the time of surgical removal. The goal of this project was to determine histological, genetic and clinical features that are associated with regional black PTC metastasis. Methods: 15 patients with black PTC metastases (black-PTC) were compared to a control cohort of 15 patients with non-black PTC metastasis (non-black PTC). Each sample was evaluated for the histological characteristics, BRAF V600E mutational status and associated patient clinical data. Results: The degree of cystic degeneration (80% vs 27% P = 0.004), percent hemosiderin deposition (20% vs 6% P = 0.001), and presence of classical variant (100% vs 67%, P = 0.018) were significantly greater in black-PTC than non-black PTC at alpha = 0.05. Other results did not test significantly different. Conclusion: This study demonstrates that black compared to non-black metastases have a greater degree of cystic degeneration and hemosiderin deposition leading to discoloration, and a trend toward an increased incidence in BRAF V600E mutations. This study is the first of its kind to describe the clinical, pathological and genetic features associated with black PTC lymph node metastasis.
Authors:
Henry S Crist; Juanita Evans; Haresh Mani; Brian Saunders; Jeffrey Fornadley; Fabian Camacho; David Goldenberg
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-24
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  -     ISSN:  1557-9077     ISO Abbreviation:  Thyroid     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Penn State University, Department of Pathology, Hershey, Pennsylvania, United States; HCRIST@hmc.psu.edu.
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