| Dizygotic twin pregnancy with a normal fetus and a nodular embryo associated with a partial hydatidiform mole. | |
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MedLine Citation:
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PMID: 20151788 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Abstract Although twin pregnancies complicated by a coexisting complete hydatidiform mole are uncommon, those with partial hydatidiform mole (PHM) are exceedingly rare; there are only several well-documented cases diagnosed antenatally. Here we present the first case of a twin placenta containing a nodular embryo associated with PHM diagnosed on routine placental examination. This dizygotic twin pregnancy featured viable embryos at 8 weeks' gestation, death of 1 embryo at 12 weeks, and delivery of a healthy infant by caesarean section at 28 weeks because of worsening maternal reflux nephropathy. Macroscopic and microscopic placental examination and fluorescence in situ hybridization showed one part of the placenta to be diploid and the other to contain a vanishing triploid embryo and a PHM, which had eluded antenatal ultrasound diagnosis. Careful pathologic examination of vanishing twins and their placentas may disclose an unexpected PHM, which can be associated, albeit infrequently, with persistent gestational trophoblastic disease or a trophoblastic tumor. |
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Authors:
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Justin William Copeland; Jerzy Stanek |
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Publication Detail:
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Type: Journal Article Date: 2010-02-12 |
Journal Detail:
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Title: Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society Volume: 13 ISSN: 1093-5266 ISO Abbreviation: Pediatr. Dev. Pathol. Publication Date: 2010 Nov-Dec |
Date Detail:
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Created Date: 2011-02-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9809673 Medline TA: Pediatr Dev Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 476-80 Citation Subset: IM |
Affiliation:
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1 Department of Anatomical Pathology, Canterbury Health Laboratories, PO Box 151, Christchurch, New Zealand. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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