Document Detail

Divide and ProsPer: the emerging role of PtdIns3P in cytokinesis.
MedLine Citation:
PMID:  20880709     Owner:  NLM     Status:  MEDLINE    
Cytokinesis is the final step of cell division whereby the dividing cells separate physically. Failure of this process has been proposed to cause tumourigenesis. Several specific lipids are essential for cytokinesis, and recent evidence has revealed that phosphatidylinositol 3-phosphate (PtdIns3P) - a well-known regulator of endosomal trafficking, receptor signaling, nutrient sensing and autophagy - plays an evolutionarily conserved role during cytokinesis. The emerging picture is that PtdIns3P and its regulators and effectors constitute a novel regulatory mechanism for cytokinesis. Elucidating the role of PtdIns3P in cytokinesis might contribute to insight into mechanisms of tumour development and suppression.
Ioannis P Nezis; Antonia P Sagona; Kay Oliver Schink; Harald Stenmark
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-09-27
Journal Detail:
Title:  Trends in cell biology     Volume:  20     ISSN:  1879-3088     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-01     Completed Date:  2010-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  642-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, Oslo, Norway.
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MeSH Terms
Fungi / cytology
Lipids / physiology
Phosphatidylinositol Phosphates / physiology*
Plants / cytology
Reg. No./Substance:
0/Lipids; 0/Phosphatidylinositol Phosphates

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