| Divide and ProsPer: the emerging role of PtdIns3P in cytokinesis. | |
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MedLine Citation:
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PMID: 20880709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cytokinesis is the final step of cell division whereby the dividing cells separate physically. Failure of this process has been proposed to cause tumourigenesis. Several specific lipids are essential for cytokinesis, and recent evidence has revealed that phosphatidylinositol 3-phosphate (PtdIns3P) - a well-known regulator of endosomal trafficking, receptor signaling, nutrient sensing and autophagy - plays an evolutionarily conserved role during cytokinesis. The emerging picture is that PtdIns3P and its regulators and effectors constitute a novel regulatory mechanism for cytokinesis. Elucidating the role of PtdIns3P in cytokinesis might contribute to insight into mechanisms of tumour development and suppression. |
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Authors:
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Ioannis P Nezis; Antonia P Sagona; Kay Oliver Schink; Harald Stenmark |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-09-27 |
Journal Detail:
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Title: Trends in cell biology Volume: 20 ISSN: 1879-3088 ISO Abbreviation: Trends Cell Biol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-01 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9200566 Medline TA: Trends Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 642-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, Oslo, Norway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cytokinesis* Fungi / cytology Humans Lipids / physiology Phosphatidylinositol Phosphates / physiology* Plants / cytology |
| Chemical | |
Reg. No./Substance:
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0/Lipids; 0/Phosphatidylinositol Phosphates |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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