Document Detail


Diverticular fistulation is associated with nicorandil usage.
MedLine Citation:
PMID:  20819332     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: We observed that a number of patients presenting to our clinic with diverticular fistulation were taking nicorandil for angina. Recognised side effects of nicorandil include gastrointestinal and genital ulceration. The aim of our study was to determine whether nicorandil is an aetiological agent in diverticular fistulation.
PATIENTS AND METHODS: We conducted a case-control study of patients with diverticular disease related enteric fistulae. Two patient groups were identified: a study group of patients with diverticular fistulae, and a control group with uncomplicated diverticular disease. The proportion of patients who had ever used nicorandil was compared between the two groups.
RESULTS: A total of 153 case notes were analysed, 69 patients with fistulae and 84 control patients with uncomplicated diverticular disease. Female to male ratio in both groups was 2:1. The mean age was 71 years in the fistula group and 69 years in the control diverticular disease group (P = ns). Of those with colonic fistulae, 16% were taking nicorandil compared with 2% of the control group (odds ratio 7.8; 95% confidence interval 1.5-39.1; P = 0.008). There was no significant difference in rates of ischaemic heart disease between fistula and control groups.
CONCLUSIONS: Nicorandil is associated with fistula formation in diverticular disease.
Authors:
James McDaid; Claire Reichl; Ihsan Hamzah; Samantha Fitter; Laura Harbach; Adrian P Savage
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of the Royal College of Surgeons of England     Volume:  92     ISSN:  1478-7083     ISO Abbreviation:  Ann R Coll Surg Engl     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-07     Completed Date:  2010-10-13     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  7506860     Medline TA:  Ann R Coll Surg Engl     Country:  England    
Other Details:
Languages:  eng     Pagination:  463-5     Citation Subset:  IM    
Affiliation:
Department of Surgery, Queen Elizabeth Hospital, Birmingham, UK. jmcdaid@doctors.net.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Angina Pectoris / drug therapy
Case-Control Studies
Diverticulum, Colon / complications*,  pathology,  therapy
Female
Humans
Intestinal Fistula / chemically induced*,  therapy
Male
Middle Aged
Nicorandil / adverse effects*,  therapeutic use
Rectovaginal Fistula / chemically induced,  therapy
Vasodilator Agents / adverse effects*,  therapeutic use
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 65141-46-0/Nicorandil
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