Document Detail


Diversity within the pRb pathway: is there a code of conduct?
MedLine Citation:
PMID:  22249267     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The failure of cell proliferation to be properly regulated is a hallmark of tumourigenesis. The retinoblastoma protein (pRb) pathway represents a key component in the regulation of the cell cycle and tumour suppression. Recent findings have revealed new levels of complexity reflecting a repertoire of post-translational modifications that occur on pRb together with its key effector E2F-1. Here we provide an overview of the modifications and consider the possibility of a 'code' that endows pRb with the ability to function in diverse physiological settings.
Authors:
S Munro; S M Carr; N B La Thangue
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-01-16
Journal Detail:
Title:  Oncogene     Volume:  31     ISSN:  1476-5594     ISO Abbreviation:  Oncogene     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-05     Completed Date:  2013-02-04     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8711562     Medline TA:  Oncogene     Country:  England    
Other Details:
Languages:  eng     Pagination:  4343-52     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetylation
Apoptosis
Cell Cycle / genetics
Cell Proliferation
E2F1 Transcription Factor / metabolism*
Humans
Methylation
Phosphorylation
Protein Processing, Post-Translational
Retinoblastoma Protein / metabolism*
Signal Transduction
Ubiquitination
Grant Support
ID/Acronym/Agency:
G1000807//Medical Research Council; //Cancer Research UK; //Medical Research Council
Chemical
Reg. No./Substance:
0/E2F1 Transcription Factor; 0/E2F1 protein, human; 0/Retinoblastoma Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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