| Diversity-oriented approaches for interrogating T-cell receptor repertoire, ligand recognition, and function. | |
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MedLine Citation:
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PMID: 23046124 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Molecular diversity lies at the heart of adaptive immunity. T-cell receptors and peptide-major histocompatibility complex molecules utilize and rely upon an enormous degree of diversity at the levels of genetics, chemistry, and structure to engage one another and carry out their functions. This high level of diversity complicates the systematic study of important aspects of T-cell biology, but recent technical advances have allowed for the ability to study diversity in a comprehensive manner. In this review, we assess insights gained into T-cell receptor function and biology from our increasingly precise ability to assess the T-cell repertoire as a whole or to perturb individual receptors with engineered reagents. We conclude with a perspective on a new class of high-affinity, non-stimulatory peptide ligands we have recently discovered using diversity-oriented techniques that challenges notions for how we think about T-cell receptor signaling. |
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Authors:
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Michael E Birnbaum; Shen Dong; K Christopher Garcia |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Immunological reviews Volume: 250 ISSN: 1600-065X ISO Abbreviation: Immunol. Rev. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-10-10 Completed Date: 2013-02-25 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 7702118 Medline TA: Immunol Rev Country: England |
Other Details:
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Languages: eng Pagination: 82-101 Citation Subset: IM |
Copyright Information:
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© 2012 John Wiley & Sons A/S. |
Affiliation:
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Department of Molecular and Cellular Physiology, Program in Immunology, Stanford University School of Medicine, CA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptive Immunity Antigen Presentation / genetics Antigens / genetics, immunology, metabolism* Binding Sites Gene Library Genetic Variation Humans Ligands Major Histocompatibility Complex / immunology* Models, Molecular Peptides / genetics, immunology, metabolism* Protein Binding Receptors, Antigen, T-Cell / genetics, immunology, metabolism* Signal Transduction / immunology T-Lymphocytes / cytology, immunology*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI048540/AI/NIAID NIH HHS; R01-AI48540/AI/NIAID NIH HHS; //Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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0/Antigens; 0/Ligands; 0/Peptides; 0/Receptors, Antigen, T-Cell |
| Comments/Corrections | |
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