Document Detail

Diversity-oriented approaches for interrogating T-cell receptor repertoire, ligand recognition, and function.
MedLine Citation:
PMID:  23046124     Owner:  NLM     Status:  MEDLINE    
Molecular diversity lies at the heart of adaptive immunity. T-cell receptors and peptide-major histocompatibility complex molecules utilize and rely upon an enormous degree of diversity at the levels of genetics, chemistry, and structure to engage one another and carry out their functions. This high level of diversity complicates the systematic study of important aspects of T-cell biology, but recent technical advances have allowed for the ability to study diversity in a comprehensive manner. In this review, we assess insights gained into T-cell receptor function and biology from our increasingly precise ability to assess the T-cell repertoire as a whole or to perturb individual receptors with engineered reagents. We conclude with a perspective on a new class of high-affinity, non-stimulatory peptide ligands we have recently discovered using diversity-oriented techniques that challenges notions for how we think about T-cell receptor signaling.
Michael E Birnbaum; Shen Dong; K Christopher Garcia
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  250     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-10     Completed Date:  2013-02-25     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  82-101     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Department of Molecular and Cellular Physiology, Program in Immunology, Stanford University School of Medicine, CA, USA.
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MeSH Terms
Adaptive Immunity
Antigen Presentation / genetics
Antigens / genetics,  immunology,  metabolism*
Binding Sites
Gene Library
Genetic Variation
Major Histocompatibility Complex / immunology*
Models, Molecular
Peptides / genetics,  immunology,  metabolism*
Protein Binding
Receptors, Antigen, T-Cell / genetics,  immunology,  metabolism*
Signal Transduction / immunology
T-Lymphocytes / cytology,  immunology*,  metabolism
Grant Support
R01 AI048540/AI/NIAID NIH HHS; R01-AI48540/AI/NIAID NIH HHS; //Howard Hughes Medical Institute
Reg. No./Substance:
0/Antigens; 0/Ligands; 0/Peptides; 0/Receptors, Antigen, T-Cell

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