Document Detail

Diversity in the molecular and cellular strategies of epithelium-to-mesenchyme transitions: Insights from the neural crest.
MedLine Citation:
PMID:  20559020     Owner:  NLM     Status:  MEDLINE    
Although epithelial to mesenchymal transitions (EMT) are often viewed as a unique event, they are characterized by a great diversity of cellular processes resulting in strikingly different outcomes. They may be complete or partial, massive or progressive, and lead to the complete disruption of the epithelium or leave it intact. Although the molecular and cellular mechanisms of EMT are being elucidated owing chiefly from studies on transformed epithelial cell lines cultured in vitro or from cancer cells, the basis of the diversity of EMT processes remains poorly understood. Clues can be collected from EMT occuring during embryonic development and which affect equally tissues of ectodermal, endodermal or mesodermal origins. Here, based on our current knowledge of the diversity of processes underlying EMT of neural crest cells in the vertebrate embryo, we propose that the time course and extent of EMT do not depend merely on the identity of the EMT transcriptional regulators and their cellular effectors but rather on the combination of molecular players recruited and on the possible coordination of EMT with other cellular processes.
Jean-Loup Duband
Publication Detail:
Type:  Journal Article     Date:  2010-07-27
Journal Detail:
Title:  Cell adhesion & migration     Volume:  4     ISSN:  1933-6926     ISO Abbreviation:  Cell Adh Migr     Publication Date:    2010 Jul-Sep
Date Detail:
Created Date:  2010-10-08     Completed Date:  2011-01-20     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101469464     Medline TA:  Cell Adh Migr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  458-82     Citation Subset:  IM    
CNRS, Laboratoire de Biologie du Développement, Paris, France.
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MeSH Terms
Cell Lineage / genetics
Epithelial-Mesenchymal Transition* / genetics
Gene Regulatory Networks / genetics
Neural Crest / cytology*,  metabolism*
Neurulation / genetics
Transcription, Genetic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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