Document Detail


Diversity in bacterial lysis systems: bacteriophages show the way.
MedLine Citation:
PMID:  23043507     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Bacteriophages have developed multiple host cell lysis strategies to promote release of descendant virions from infected bacteria. This review is focused on the lysis mechanisms employed by tailed double-stranded DNA bacteriophages, where new developments have recently emerged. These phages seem to use a least common denominator to induce lysis, the so called holin-endolysin dyad. Endolysins are cell wall degrading enzymes whereas holins form "holes" in the cytoplasmic membrane at a precise scheduled time. The latter function was for long viewed as essential to provide a pathway for endolysin escape to the cell wall. However, recent studies have shown that phages can also exploit the host cell secretion machinery to deliver endolysins to their target and subvert the bacterial autolytic arsenal to effectively accomplish lysis. In these systems the membrane-depolarizing holin function still seems to be essential to activate secreted endolysins. New lysis players have also been uncovered that promote degradation of particular bacterial cell envelopes like that of Mycobacteria. © 2012 Federation of European Microbiological Societies. Published by BlackwellPublishing Ltd. All rights reserved.
Authors:
Maria João Catalão; Filipa Gil; José Moniz-Pereira; Carlos São-José; Madalena Pimentel
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-9
Journal Detail:
Title:  FEMS microbiology reviews     Volume:  -     ISSN:  1574-6976     ISO Abbreviation:  FEMS Microbiol. Rev.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902526     Medline TA:  FEMS Microbiol Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.
Affiliation:
Centro de Patogénese Molecular, Unidade dos Retrovírus e Infecções Associadas, Faculty of Pharmacy, University of Lisbon, Av. Prof. Gama Pinto, 1649-003, Lisbon, Portugal.
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