Document Detail


Diversity in mechanisms of endothelium-dependent vasodilation in health and disease.
MedLine Citation:
PMID:  23311975     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Small arterioles (40-150 μm) contribute to the majority of vascular resistance within organs and tissues. Under resting conditions, the basal tone of these vessels is determined by a delicate balance between vasodilator and vasoconstrictor influences. Cardiovascular homeostasis and regional tissue perfusion is largely a function of the ability of these small blood vessels to constrict or dilate in response to the changing metabolic demands of specific tissues. The endothelial cell layer of these microvessels is a key modulator of vasodilation through the synthesis and release of vasoactive substances. Beyond their vasomotor properties, these compounds importantly modulate vascular cell proliferation, inflammation, and thrombosis. Thus, the balance between local regulation of vascular tone and vascular pathophysiology can vary depending upon which factors are released from the endothelium. This review will focus on the dynamic nature of the endothelial released dilator factors depending on species, anatomic site, and presence of disease, with a focus on the human coronary microcirculation. Knowledge how endothelial signaling changes with disease may provide insights into the early stages of developing vascular inflammation and atherosclerosis, or related vascular pathologies.
Authors:
Matthew J Durand; David D Gutterman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Microcirculation (New York, N.Y. : 1994)     Volume:  20     ISSN:  1549-8719     ISO Abbreviation:  Microcirculation     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-11     Completed Date:  2013-11-01     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  9434935     Medline TA:  Microcirculation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  239-47     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons Ltd.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arterioles / pathology,  physiopathology*
Atherosclerosis / pathology,  physiopathology*
Endothelium, Vascular / pathology,  physiopathology*
Humans
Vascular Resistance*
Vasculitis / pathology,  physiopathology*
Vasodilation*
Grant Support
ID/Acronym/Agency:
HL007792/HL/NHLBI NIH HHS; HL094971/HL/NHLBI NIH HHS; R01 HL094971/HL/NHLBI NIH HHS; R01 HL113612/HL/NHLBI NIH HHS
Comments/Corrections

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