Document Detail


Diversity of WD-repeat proteins.
MedLine Citation:
PMID:  18925368     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The WD-repeat-containing proteins form a very large family that is diverse in both its function and domain structure. Within all these proteins the WD-repeat domains are thought to have two common features: the domain folds into a beta propeller; and the domains form a platform without any catalytic activity on which multiple protein complexes assemble reversibly. The fact that these proteins play such key roles in the formation of protein-protein complexes in nearly all the major pathways and organelles unique to eukaryotic cells has two important implications. It supports both their ancient and proto eukaryotic origins and supports a likely association with many genetic diseases.
Authors:
Temple F Smith
Related Documents :
8402898 - The gtpase dynamin binds to and is activated by a subset of sh3 domains.
23583778 - The four canonical tpr subunits of human apc/c form related homo-dimeric structures and...
24770668 - Fabrication of enzyme-degradable and size-controlled protein nanowires using single par...
12668758 - Regulation of myotubularin-related (mtmr)2 phosphatidylinositol phosphatase by mtmr5, a...
20206698 - Esprit: an automated, library-based method for mapping and soluble expression of protei...
11010808 - Immunoelectron microscopy provides evidence that tumor necrosis factor receptor-associa...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Sub-cellular biochemistry     Volume:  48     ISSN:  0306-0225     ISO Abbreviation:  Subcell. Biochem.     Publication Date:  2008  
Date Detail:
Created Date:  2008-10-17     Completed Date:  2008-11-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0316571     Medline TA:  Subcell Biochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  20-30     Citation Subset:  IM    
Affiliation:
BioMolecular Engineering Research Center, College of Engineering, Boston University, 36 Cummington Street, Boston, MA 02215, USA. tsmith@darwin.bu.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Carrier Proteins / chemistry*
Catalysis
Models, Molecular
Protein Conformation
Chemical
Reg. No./Substance:
0/Carrier Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Phylogenetic, structural and functional relationships between WD- and Kelch-repeat proteins.
Next Document:  Molecular phylogeny and evolution of the coronin gene family.