Document Detail


Diversity of IL-17-producing T lymphocytes.
MedLine Citation:
PMID:  23052209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interleukin (IL)-17 is a pro-inflammatory cytokine that plays critical roles in host defense against extracellular bacteria and fungi and also in the pathogenesis of autoimmune diseases. While CD4+ TCRαβ+ T helper (Th) 17 cells are the best-described cellular source of IL-17, many innate-like T cells are in fact potent producers of IL-17. Given the increasing interest in therapeutic modulation of the IL-17 axis, it is crucial to better understand the cellular origins of IL-17 in various infection and diseases settings. While the diverse population of IL-17-producing T cells share many common characteristics, notable differences also exist. In this review, we discuss the heterogeneity of IL-17-producing T cell types focusing on their development, regulation, and function.
Authors:
Jiyeon S Kim; Martha S Jordan
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-10-04
Journal Detail:
Title:  Cellular and molecular life sciences : CMLS     Volume:  70     ISSN:  1420-9071     ISO Abbreviation:  Cell. Mol. Life Sci.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-10     Completed Date:  2013-08-27     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  9705402     Medline TA:  Cell Mol Life Sci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  2271-90     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoimmunity
Cytokines / metabolism
Humans
Models, Immunological
Neoplasms / immunology
Receptors, Antigen, T-Cell / metabolism
Signal Transduction
Th17 Cells / classification*,  cytology,  physiology
Transcription Factors / metabolism,  physiology
Grant Support
ID/Acronym/Agency:
K01 AR052802/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines; 0/Receptors, Antigen, T-Cell; 0/Transcription Factors
Comments/Corrections

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