| Diversity of bile salts in fish and amphibians: evolution of a complex biochemical pathway. | |
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MedLine Citation:
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PMID: 20113173 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bile salts are the major end metabolites of cholesterol and are also important in lipid and protein digestion, as well as shaping of the gut microflora. Previous studies had demonstrated variation of bile salt structures across vertebrate species. We greatly extend prior surveys of bile salt variation in fish and amphibians, particularly in analysis of the biliary bile salts of Agnatha and Chondrichthyes. While there is significant structural variation of bile salts across all fish orders, bile salt profiles are generally stable within orders of fish and do not correlate with differences in diet. This large data set allowed us to infer evolutionary changes in the bile salt synthetic pathway. The hypothesized ancestral bile salt synthetic pathway, likely exemplified in extant hagfish, is simpler and much shorter than the pathway of most teleost fish and terrestrial vertebrates. Thus, the bile salt synthetic pathway has become longer and more complex throughout vertebrate evolution. Analysis of the evolution of bile salt synthetic pathways provides a rich model system for the molecular evolution of a complex biochemical pathway in vertebrates. |
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Authors:
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Lee R Hagey; Peter R Møller; Alan F Hofmann; Matthew D Krasowski |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Physiological and biochemical zoology : PBZ Volume: 83 ISSN: 1537-5293 ISO Abbreviation: Physiol. Biochem. Zool. Publication Date: 2010 Mar-Apr |
Date Detail:
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Created Date: 2010-02-15 Completed Date: 2010-05-03 Revised Date: 2010-09-27 |
Medline Journal Info:
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Nlm Unique ID: 100883369 Medline TA: Physiol Biochem Zool Country: United States |
Other Details:
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Languages: eng Pagination: 308-21 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of California-San Diego, MC 0063, La Jolla, California 92093, USA. lhagey@ucsd.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amphibians
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metabolism*,
physiology Animals Bile Acids and Salts / biosynthesis*, chemistry, classification, metabolism, physiology Biosynthetic Pathways / physiology* Cholestanols / metabolism Elasmobranchii / metabolism, physiology Evolution* Fishes / metabolism*, physiology Gas Chromatography-Mass Spectrometry Hagfishes / metabolism, physiology Magnetic Resonance Spectroscopy Mass Spectrometry Petromyzon / metabolism, physiology Phylogeny |
| Grant Support | |
ID/Acronym/Agency:
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DK 64891/DK/NIDDK NIH HHS; K08 GM074238-04/GM/NIGMS NIH HHS; K08-GM074238/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 0/Cholestanols |
| Comments/Corrections | |
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