Document Detail


Diversity of Abeta deposits in the aged brain: a window on molecular heterogeneity?
MedLine Citation:
PMID:  18273496     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Abeta peptide forms a morphologically heterogeneous assortment of aggregates in the brains of patients with Alzheimer's disease. The reasons for the diversity of the histopathologically identified lesions (Abeta-plaques and cerebral beta-amyloid angiopathy) are uncertain. However, there is growing evidence for the existence of higher order structural heterogeneity in protein molecules with the same amino acid sequence and differential involvement in disease. Focused analysis of plaque morphotypes could yield novel insights into the organization and function of putative protein variants in the diseased brain. In addition to classical amyloid-selective dyes, new techniques are emerging to undertake such analyses, including selective, small molecule binding agents, specific antibodies, and conformationally sensitive optical probes. By illuminating the relationships between specific lesions and their molecular components, these agents can help to clarify the complex pathology of Alzheimer's disease.
Authors:
L C Walker; Rebecca F Rosen; H Levine
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie     Volume:  49     ISSN:  1220-0522     ISO Abbreviation:  Rom J Morphol Embryol     Publication Date:  2008  
Date Detail:
Created Date:  2008-02-14     Completed Date:  2008-09-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112454     Medline TA:  Rom J Morphol Embryol     Country:  Romania    
Other Details:
Languages:  eng     Pagination:  5-11     Citation Subset:  IM    
Affiliation:
Yerkes National Primate Research Center and Department of Neurology, Emory University, Atlanta, GA 30322, USA. lary.walker@emory.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Alzheimer Disease / genetics,  metabolism
Amyloid beta-Protein / chemistry*,  genetics,  metabolism
Brain Chemistry / physiology
Genetic Heterogeneity
Humans
Senile Plaques / chemistry*,  genetics
Grant Support
ID/Acronym/Agency:
P01 AG026423-01A2/AG/NIA NIH HHS; RR-00165/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Amyloid beta-Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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