| Diversity of ACTH-immunoreactive cells in the human adenohypophysis: an immunohistochemical study with special reference to cluster formation and follicular cell association. | |
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MedLine Citation:
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PMID: 17159248 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Horvath et al. called relatively small ACTH-immunoreactive (ACTH-IR) cells observed in basophil invasion "proopiomelanocortin (POMC) cells," and these cells were supposed to be different from larger ACTH-IR cells in human adenohypophysis. To clarify the existence of "anterior POMC cells," we examined 21 autopsy cases taking note of follicular cells (FCs). We found that smaller ACTH-IR cells were clustered forming small areas without FC association, clustered small cell island (CSCI). CSCI was found in all the specimens we examined using immunohistochemical staining for ACTH and cytokeratin (AE1/AE3) in serial sections. ACTH-IR cells outside CSCI were of various sizes, mainly consisting of larger ACTH-IR cells that were diffusely scattered among other hormone-secreting cells and closely associated with FCs. By immunohistochemistry, ACTH-IR cells within CSCI and basophil invasion showed uniformly weak reactivity and common patterns for cytokeratins (CAM5.2 and 35 beta H11), carboxypeptidase D, and LeuM1, whereas those outside CSCI showed a great variety of immunoreactivity. The similarity in the immunoreactivity of ACTH-IR cells between CSCI and basophil invasion suggests that ACTH-IR cells in these two areas have common characteristics and ACTH-IR cells in CSCI are most likely "POMC cells." The clustered "anterior POMC cells" may be distinguishable by light microscopic immunohistochemistry. |
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Authors:
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Michiko Yamashita; Toshiaki Sano; Zhi Rong Qian; Kalman Kovacs; Eva Horvath |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Endocrine pathology Volume: 17 ISSN: 1046-3976 ISO Abbreviation: Endocr. Pathol. Publication Date: 2006 |
Date Detail:
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Created Date: 2006-12-12 Completed Date: 2007-02-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9009288 Medline TA: Endocr Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 155-64 Citation Subset: IM |
Affiliation:
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Department of Human Pathology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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biosynthesis* Aged Basophils / metabolism Female Humans Immunohistochemistry Male Middle Aged Pituitary Gland, Anterior / cytology*, metabolism* Pro-Opiomelanocortin / metabolism |
| Chemical | |
Reg. No./Substance:
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66796-54-1/Pro-Opiomelanocortin; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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