Document Detail

Diversity of ACTH-immunoreactive cells in the human adenohypophysis: an immunohistochemical study with special reference to cluster formation and follicular cell association.
MedLine Citation:
PMID:  17159248     Owner:  NLM     Status:  MEDLINE    
Horvath et al. called relatively small ACTH-immunoreactive (ACTH-IR) cells observed in basophil invasion "proopiomelanocortin (POMC) cells," and these cells were supposed to be different from larger ACTH-IR cells in human adenohypophysis. To clarify the existence of "anterior POMC cells," we examined 21 autopsy cases taking note of follicular cells (FCs). We found that smaller ACTH-IR cells were clustered forming small areas without FC association, clustered small cell island (CSCI). CSCI was found in all the specimens we examined using immunohistochemical staining for ACTH and cytokeratin (AE1/AE3) in serial sections. ACTH-IR cells outside CSCI were of various sizes, mainly consisting of larger ACTH-IR cells that were diffusely scattered among other hormone-secreting cells and closely associated with FCs. By immunohistochemistry, ACTH-IR cells within CSCI and basophil invasion showed uniformly weak reactivity and common patterns for cytokeratins (CAM5.2 and 35 beta H11), carboxypeptidase D, and LeuM1, whereas those outside CSCI showed a great variety of immunoreactivity. The similarity in the immunoreactivity of ACTH-IR cells between CSCI and basophil invasion suggests that ACTH-IR cells in these two areas have common characteristics and ACTH-IR cells in CSCI are most likely "POMC cells." The clustered "anterior POMC cells" may be distinguishable by light microscopic immunohistochemistry.
Michiko Yamashita; Toshiaki Sano; Zhi Rong Qian; Kalman Kovacs; Eva Horvath
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Endocrine pathology     Volume:  17     ISSN:  1046-3976     ISO Abbreviation:  Endocr. Pathol.     Publication Date:  2006  
Date Detail:
Created Date:  2006-12-12     Completed Date:  2007-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9009288     Medline TA:  Endocr Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  155-64     Citation Subset:  IM    
Department of Human Pathology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.
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MeSH Terms
Adrenocorticotropic Hormone / biosynthesis*
Basophils / metabolism
Middle Aged
Pituitary Gland, Anterior / cytology*,  metabolism*
Pro-Opiomelanocortin / metabolism
Reg. No./Substance:
66796-54-1/Pro-Opiomelanocortin; 9002-60-2/Adrenocorticotropic Hormone

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