| Diverse regulatory roles for lysosomal proteases in the immune response. | |
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MedLine Citation:
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PMID: 19637232 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The innate and adaptive immune system utilise endocytic protease activity to promote functional immune responses. Cysteine and aspartic proteases (cathepsins) constitute a subset of endocytic proteases, the immune function of which has been described extensively. Although historically these studies have focused on their role in processes such as antigen presentation and zymogen processing within the endocytic compartment, recent discoveries have demonstrated a critical role for these proteases in other intracellular compartments, and within the extracellular milieu. It has also become clear that their pattern of expression and substrate specificities are more diverse than was first envisaged. Here, we discuss recent advances addressing the role of lysosomal proteases in various aspects of the immune response. We pay attention to reports demonstrating cathepsin activity outside of its canonical endosome/lysosome microenvironment. |
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Authors:
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Jeff D Colbert; Stephen P Matthews; Gail Miller; Colin Watts |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of immunology Volume: 39 ISSN: 1521-4141 ISO Abbreviation: Eur. J. Immunol. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2010-01-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1273201 Medline TA: Eur J Immunol Country: Germany |
Other Details:
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Languages: eng Pagination: 2955-65 Citation Subset: IM |
Affiliation:
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Division of Cell biology & Immunology, College of Life Sciences, University of Dundee, Dundee, UK. |
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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//Medical Research Council; //Wellcome Trust |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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