Document Detail


Diverse functions of Hedgehog signaling in formation and physiology of steroidogenic organs.
MedLine Citation:
PMID:  20422709     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adrenal, testis, and ovary are steroidogenic organs derived from a common primordium that consists of steroidogenic factor 1 (SF1)-positive precursor cells. SF1 not only defines the steroidogenic lineages in these organs but also controls their differentiation. Recent evidence implicates the Hedgehog (Hh) signaling pathway as a downstream regulator of SF1 in the appearance of steroidogenic cells in these organs. The Hh signaling pathway serves as a common crosstalk component, yet has evolved diverse functions in the expansion and differentiation of the steroidogenic cells in a tissue-specific manner. The purpose of this review is to compare and contrast the different roles of Hh signaling in these three organs during development.
Authors:
Chen-Che Jeff Huang; Humphrey Hung-Chang Yao
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Molecular reproduction and development     Volume:  77     ISSN:  1098-2795     ISO Abbreviation:  Mol. Reprod. Dev.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-04-27     Completed Date:  2010-07-19     Revised Date:  2013-03-14    
Medline Journal Info:
Nlm Unique ID:  8903333     Medline TA:  Mol Reprod Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  489-96     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Wiley-Liss, Inc.
Affiliation:
Department of Veterinary Biosciences, University of Illinois, Urbana, IL 61802, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Glands* / cytology,  embryology,  metabolism
Animals
Cell Lineage
Female
Hedgehog Proteins / genetics,  metabolism*
Male
Ovary* / cytology,  embryology,  metabolism
Signal Transduction / physiology*
Testis* / cytology,  embryology,  metabolism
Grant Support
ID/Acronym/Agency:
HD46861/HD/NICHD NIH HHS; R01 HD046861/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Hedgehog Proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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