Document Detail

Diverse electrophysiological spectrum of the Lambert-Eaton myasthenic syndrome.
MedLine Citation:
PMID:  2725573     Owner:  NLM     Status:  MEDLINE    
Among 13 patients with the Lambert-Eaton myathenic syndrome (LEMS), three different patterns on the repetitive nerve stimulation test were observed at the time of initial testing. Type 1 pattern, seen in one patient, had low normal CMAP amplitude, decremental response at the low rate of stimulation (LRS), and relatively normal response at the high rate of stimulation (HRS). Type 2, seen in nine patients, had the classical triad: low CMAP amplitude, decremental response at LRS, and incremental response at HRS. Type 3, seen in three patients, showed low CMAP amplitude, decremental response at LRS, and initial decremental response at HRS. We believe that these three patterns represent different degrees of blocking in LEMS, from the mildest in type 1 to the most severe in type 3. Since types 1 and 3 can be misinterpreted as myasthenia gravis patterns, they must be recognized in LEMS and an incremental response documented by prolonged stimulation at HRS.
S J Oh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Muscle & nerve     Volume:  12     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-07-05     Completed Date:  1989-07-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  464-9     Citation Subset:  IM    
Department of Neurology, University of Alabama, Birmingham 35294.
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MeSH Terms
Action Potentials
Electric Stimulation
Middle Aged
Muscles / physiopathology
Neuromuscular Diseases / diagnosis,  physiopathology*

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