| Diverse basal and stress-related phenotypes of Sprague Dawley rats from three vendors. | |
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MedLine Citation:
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PMID: 16935312 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Based on observed phenotypic differences in growth and ACTH responses to stress in Sprague Dawley rats obtained from different vendors, we ran head-to-head comparisons on rats obtained from three different vendors, Harlan, Charles River, and Simonsen, with respect to baseline phenotypic differences and a metabolic feedback hypothesis of hypothalamo-pituitary-adrenal (HPA) regulation. Charles River and Harlan rats gained weight faster than Simonsen rats, but chow intake standardized for body weight was not increased, consistent with their greater caloric efficiency. Weight gain was inversely related with mean daily temperatures, without differences in activity levels. Half of the animals given lard and 32% sucrose solutions in addition to chow increased caloric intake and core temperature, decreased caloric efficiency, and increased fat depots, leptin, and in Simonsen rats, insulin. A 5-day regimen of once-daily 2-h restraint decreased feeding and caloric efficiency. Rats from two vendors with the availability of sucrose and lard, Charles River and Simonsen, showed blunted HPA responses to restraint compared to chow controls, whereas the Harlans exhibited no adrenocorticotropin (ACTH) response and an amplified adrenocortical response on the high-energy diet compared to chow controls. Substantial phenotypic differences exist between Sprague Dawley rats from different vendors with respect to metabolism and HPA function. The metabolic feedback hypothesis was supported in two of the three vendors' rats. |
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Authors:
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Norman Pecoraro; Abigail B Ginsberg; James P Warne; Francisca Gomez; Susanne E la Fleur; Mary F Dallman |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2006-08-28 |
Journal Detail:
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Title: Physiology & behavior Volume: 89 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-10-30 Completed Date: 2007-01-04 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: United States |
Other Details:
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Languages: eng Pagination: 598-610 Citation Subset: IM |
Affiliation:
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Department of Physiology, School of Medicine, University of California San Francisco, 94143-0444, United States. norman.pecoraro@ucsf.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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blood Animals Basal Metabolism / physiology* Body Composition / physiology* Body Temperature / physiology Body Weight / physiology Corticosterone / blood Energy Intake / physiology Feeding Behavior / physiology Hypothalamo-Hypophyseal System / physiology* Insulin / blood Leptin / blood Male Phenotype Pituitary-Adrenal System / physiology* Rats Rats, Sprague-Dawley / physiology* Species Specificity Stress, Psychological / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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DA 016944/DA/NIDA NIH HHS; DK 28172/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Leptin; 11061-68-0/Insulin; 50-22-6/Corticosterone; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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