Document Detail

Diverse Families of Antimicrobial Peptides Isolated from Skin Secretions of Three Species of East Asian Frogs, Babina daunchina, Babina adenopleura, and Rana omeimontis (Ranidae).
MedLine Citation:
PMID:  25001915     Owner:  NLM     Status:  In-Data-Review    
Twenty-two novel cDNAs encoding 22 peptide precursors for 19 mature peptides including antimicrobial peptides (AMPs) were identified from East Asian frog species Babina daunchina, Babina adenopleura, and Rana omeimontis skin-derived cDNA libraries. Two atypical members of the brevinin-1 family AMPs, named brevinin-1AN1 (FLTGVLKLASKIPSVLCAVLKTC) and brevinin-1DN1(FLKGVINLASKIPSMLCAVLKTC), were purified from the skin secretions of B. adenopleura and B. daunchina, respectively. A member of the ranatuerin-2 family AMP named ranatuerin-2DN1 (GLFDSITQGLKDTAVKLLDKIKCKLSACPPA) was also purified from the skin secretion of B. daunchina. One AMP named japonicin-2OM1 (FIVPSIFLLKKAFCIALKKNC) was purified from the skin secretion of R. omeimontis. The antimicrobial tests showed that brevinin-1DN1, brevinin-1DN2, brevinin-1AN1, and japonicin-2OM1 possess higher antimicrobial activity against Gram-positive bacteria than Gram-negative bacteria.
Yuhong Hu; Shiqi Xu; Yonghong Hu; Chao Guo; Hao Meng; Jing Li; Jingze Liu; Hui Wang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zoological science     Volume:  31     ISSN:  0289-0003     ISO Abbreviation:  Zool. Sci.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-07-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8702287     Medline TA:  Zoolog Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  438-44     Citation Subset:  IM    
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