| Diverging sex-specific long-term effects of cigarette smoking on fasting insulin and glucose levels in non-diabetic people. | |
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MedLine Citation:
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PMID: 22019949 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES: We determined in non-diabetic persons the associations of current smoking with future glucose and insulin concentrations. DESIGN AND METHODS: Middle-aged non-diabetic adults (n=1071) were studied in whom these values were measured at baseline and 5.2-years later. RESULTS: Age-adjusted fasting insulin concentrations in 137 smoking men remained lower than never smokers at both surveys. While age-adjusted fasting glucose values in male never smokers declined at follow-up (p=0.037), they rose in male smokers. In 94 female smokers, age-adjusted fasting insulin values marginally declined, and fasting glucose was reduced (by 0.09mmol/L, p=0.055) during follow-up. In contrast in never-smoking women, insulin and glucose concentrations rose (p<0.001 in both). Age-adjusted insulin levels in former smokers exhibited similar trends as never smokers. Trends were essentially unchanged when adjustment included body mass index. Current male smokers demonstrated evidence of reduced insulin sensitivity, female smokers of improved one, as assessed by QUICKI. CONCLUSION: Smoking among Turks induces at long-term lower fasting insulin levels which represent improved insulin sensitivity in women, yet a reduced one in men. |
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Authors:
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Altan Onat; Günay Can; Gökhan Ciçek; Yüksel Doğan; Hasan Kaya; Hasan Ali Gümrükçüoğlu; Hüsniye Yüksel |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-12 |
Journal Detail:
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Title: Clinical biochemistry Volume: - ISSN: 1873-2933 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
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Department of Cardiology, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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