Document Detail


Divergent selection for immune responsiveness in chickens: estimation of realized heritability with an animal model.
MedLine Citation:
PMID:  1429274     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
With the aim of improving general disease resistance, chickens were divergently selected for their antibody titers 5 d after immunization with sheep red blood cells for nine generations. Selected and control lines differed significantly for primary and secondary responses after three generations. Heritability of the antibody titer was estimated by REML fitting an animal model using a derivative-free algorithm. The heritability estimate using data on all lines simultaneously was .31. Realized heritability of the antibody titer in the selected lines was estimated by using either the phenotypic cumulative response as the deviation from the control line or the mean breeding values obtained with an animal model. Values from the two methods were consistent, giving a realized heritability of .21 and .25 in the high and low lines, respectively. The genetic trend was not linear and the response to selection tended to accelerate over generations.
Authors:
M H Pinard; J A van Arendonk; M G Nieuwland; A J van der Zijpp
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of animal science     Volume:  70     ISSN:  0021-8812     ISO Abbreviation:  J. Anim. Sci.     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1992-12-01     Completed Date:  1992-12-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8003002     Medline TA:  J Anim Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2986-93     Citation Subset:  IM    
Affiliation:
Department of Animal Husbandry, Wageningen Agricultural University, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibody Formation / genetics*
Breeding*
Chickens / genetics,  immunology*
Female
Immunoglobulin G / biosynthesis
Inbreeding
Male
Models, Genetic*
Chemical
Reg. No./Substance:
0/Immunoglobulin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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